Prabir Kumar Mukhopadhyay

Professor and Head of the Department

• B Sc in Physiology (Calcutta University, 1981)
• M Sc in Physiology (Calcutta University, 1983)
• Ph D in Science (Jadavpur University, 1995)

My first assignment with Krishnagar Govt. College as WBES  brought me from the area of hard-core Biochemical research to the world of teaching and this gave me the opportunity to explore my teaching ability and also to develop the teacher-student inter-personal relationship. During my service period at KGC, I completed the necessary UGC course curriculum and also achieved the PhD degree from the Jadavpur University on the basis of the studies done at Indian Institute of Chemical Biology. The Presidency University is considered as a ‘mine of talents’ and always I try to improvise them for the three’s (dedication, desire and sincerity), as if ‘the dream for touching the sky would be possible’. 

With the descriptive knowledge on classical Endocrinology and Reproductive Physiology I entered in the area of research where I had to concentrate on finding the ontogeny, characterization and functional significance of a newly isolated implantation-specific lectin (mannose binding protein). While doing all the related studies at Indian Institute of Chemical Biology, Jadavpur, I also learned the techniques of protein isolation and purification. So far the scientific activities performed at the Presidency University, Kolkata, all have been done with the PG students through their dissertation studies. Topics currently actively researched include the arsenic toxicity protection in male and female reproductive system functions by different dietary factors. Now I am also engaged in finding the extent of toxicity development in some other body systems and the subsequent amelioration by the altered dietary regime. I am also performing some studies on diabetic-induced animal models for herbal remediation from diabetogenic effects. Furthermore, the studies with these dietary factors in the search of protection of some altered hematological parameters and erythrocytes deformability in arsenic exposed male rats have shown very surprising results. Further in-depth studies are required for finding the mechanism behind the toxicity management.

Since last  30 years at UG classes I teach the different classical systems of which the mostly taught areas are photoperiodism, oxidative stress parameters, respiration, skin and thermoregulation, lipid biochemistry, receptors and biosignaling, neuroendocrinogy, endocrinology and pathophysiology, reproductive system (male & female) and the techniques like hematology along with histology.  In PG classes the mostly covered areas are receptors and cell signaling, molecular endocrinology, reproductive pathophysiology, disorders of lipid metabolism and the application/role of histology, histomorphometry, histochemistryand immunohistochemistry in toxicology research. Students from other institutes like IISER Kolkata and SRM Institute of Science and Technology, Chennai, Tamilnadu have carried out their Summer Internship Programme.

More than thirty five students have completed the project studies at the PG final year and submitted their Dissertation Thesis under my guidance. Presently three students are pursuing their  PhD under my guidance.

I am the Life-Member of the following academic bodies.

•    Indian Association of Biomedical Scientist
•    Physiological Society of India 
•    Life member of Indian Society for the Study of Reproduction and Fertility (ISSRF)
•    Life member of Indian Science Congress Association (ISCA)

1. Maity, J., Pal, P., Pal, R. et al. Co-administration of L-Ascorbic Acid and α-Tocopherol Alleviates Arsenic-Induced Immunotoxicities in the Thymus and Spleen by Dwindling Oxidative Stress-Induced Inflammation. Biol Trace Elem Res (2023). https://doi.org/10.1007/s12011-023-03841-7

2. Maity, J., Majumder, S., Pal, R., Saha, B., Mukhopadhyay, P. K. (2023).Ascorbic acid modulates immune responses through Jumonji C domain containing histone demethylases and ten eleven translocation (TET)methylcytosine dioxygenase. BioEssays. https://doi.org/10.1002/bies.202300035

3. Mondal R, Pal P, Biswas S, Chattopadhyay A, Bandyopadhyay A, Mukhopadhyay A, Mukhopadhyay PK. Attenuation of sodium arsenite mediated ovarian DNA damage, follicular atresia, and oxidative injury by combined application of vitamin E and C in post pubertal Wistar rats. NaunynSchmiedebergs Arch Pharmacol. 2023 Oct;396(10):2701-2720.

4. Biswas S, Pal P, Mondal R, Mukhopadhyay PK. Casein and pea enriched high-protein diet attenuates arsenic provoked apoptosis in testicles of adult rats. Toxicol Res (Camb). 2023 Jun 14;12(4):551-563.

5. Pal P, Jha NK, Pal D, Jha SK, Anand U, Gopalakrishnan AV, Dey A, Mukhopadhyay PK. Molecular basis of fluoride toxicities: Beyond benefits and implications in human disorders. Genes Dis. 2022 Sep 21;10(4):1470-1493.

6. Mondal R, Mukhopadhyay A, Chattopadhyay, Bandyopadhyay A, Mukhopadhyay PK. Ovarian follicular atresia and uterine toxicity after subchronic oral exposure of postpubertal rats to sodium arsenite.Comp Clin Path. 2022; 31:597–612

7. Dalal S, Adhikary J, Roy A, Biswas SS, Mukhopadhyay PK, Acharya S, Ghosh A. Impact of hyperglycemia on the expression of GLUT1 during oral carcinogenesis in rats. Mol Biol Rep. 2022 Sep;49(9):8369-8380.

8. Pal P, De A, Roychowdhury T, Mukhopadhyay PK. Vitamin C and E supplementation can ameliorate NaF mediated testicular and spermatozoal DNA damages in adult Wistar rats. Biomarkers. 2022 Mar; 27(4):361-374.

9. Pal P, Biswas S, Mukhopadhyay PK. Molecular perspective concerning fluoride and arsenic mediated disorders on epididymal maturation of spermatozoa: A concise review. Hum ExpToxicol. 2021 Dec;40(12):2025-2038.

10. Pal P, Mukhopadhyay PK. Fluoride induced testicular toxicities in adult Wistar rats. ToxicolMech Methods. 2021 Jun;31(5):383-392.

11. Biswas S, Kumar Mukhopadhyay PK. Casein- and pea-enriched high-protein diet can take care of the reprotoxic effects of arsenic in male rats. Andrologia. 2020 Jun;52(5):e13560.

12. Biswas P, Mukhopadhyay A, Syed NK, Mukhopadhyay PK. High-Protein Diet Ameliorates Arsenic-Induced Oxidative Stress and Antagonizes Uterine Apoptosis in Rats. Biological Trace Element Research. https://doi.org/10.1007/s12011-019-1657-2

13. Ghosh S, Mishra R, Biswas S, Bhadra RK, Mukhopadhyay PK. α-Lipoic Acid Mitigates Arsenic-Induced Hematological Abnormalities in Adult Male Rats. Iranian journal of medical sciences. 2017 May; 42(3):242.

14. Mondal R, Biswas S, Chatterjee A, Mishra R, Mukhopadhyay A, Bhadra RK, Mukhopadhyay PK. Protection against arsenic-induced hematological and hepatic anomalies by supplementation of vitamin C and vitamin E in adult male rats. J Basic ClinPhysiolPharmacol. 2016 Jul 27..

15. GopiNathBanik, Indrani Chakraborty, Mukhopadhyay P K. Ameliorative Effect of α-tocopherol and Ascorbic Acid on the Accessory Reproductive Glands of Adult Male Rats in Arsenic Toxicity. Int. J. Pharm. Sci. Rev. Res., 26(2), May – Jun 2014; Article No. 48, Pages: 282-287.

16. Mukhopadhyay P K, Dey A, Mukherjee S, and Pradhan NK. The effect of coadiministration of α-tocopherol and ascorbic acid on arsenic trioxide-induced testicular toxicity in adult rats. J Basic ClinPhysiolPhamacol (2013), 24 (4), 245-53

17. Mondal, S., Mukherjee, S., Chowdhury, K., Kabir, S N. and Mukhopadhyay, P K. (2013). Prevention of arsenic-mediatedreproductive toxicity in adult female rats by high protein diet. Pharmaceutical Biology,2013; 51(11): 1363–1371

18. Dey, A., Bose, A. and Mukhopadhyay, P K. (2011).Testicular toxicity in arsenic exposed albino rats: ameliorative effects of ascorbic acid and α-tocopherol. Biomedicine, 31(1) 53-63.

19. Mukherjee, S. and Mukhopadhyay, P K. (2009). Studies on arsenic toxicity in male rat gonads and its protection by high dietary protein supplementation. Al Ameen J Med Sci, 2 73-77.

20. Das, M., Mukhopadhyay, P K. and Chowdhury, M. (1994). Carbohydrate-binding profile of a pregnancy associated rat uterine glycoprotein. Molecular and Cellular Biochemistry, 137 91-99.

21. Mukhopadhyay, P K. and Chowdhury, M. (1993). Pregnancy-associated mannose binding protein of the rat uterus: possible role in implantation. Lectins: Biology, Biochemistry, Clinical Biochemistry, 9 105-109.

22. Mukhopadhyay, P K. and Chowdhury, M. (1989) Ontogeny and implication of pregnancy associated agglutinin of rat uterus. J ReprodFert , 86 59-63.

Book chapters:

1. Pal P, Biswas S, Mondal R, Mukhopadhyay PK. Book Title: The Role of Reactive Oxygen Species in Health and Disease; Book ID: _21293; Chapter Title: Fluoride and Arsenic Mediated Oxidative Damage Can Cause Disorders in Reproductive System; Chapter ID: 82158; (In Press) Nova Science Publishers, Inc.415 Oser Avenue, Suite NHauppauge, NY 11788 USA

2. M. Chowdhury, P.K. Mukhopadhyay and M. Das. Cellular and Molecular Signaling in Reproduction – chapter entitled “Hormonal regulation of a sugar-binding protein of rat uterus which participates in implantation.” New Age International Publishers, New Delhi, 1996, pp-123-128.

3. A. Mukhopadhyay, R. Mondal, S. Biswas, P.K. Mukhopadhyay. Molecular physiological and nutritional responses during pathophysiological alteration of cell function - chapter entitled “Arsenic mediated Female Reproductive disorders and its possible protection.”Aaheli Publishers, Kolkata, 2017, pp-9-21.