Santanu Chakraborty

Assistant Professor

B.Sc in Zoology  (Calcutta University: 1994-1997)

M.Sc in Zoology (Calcutta University: 1997-1999)

PhD. in Molecular Physiology (Miami University, Ohio, USA: 2001-2006)

Postdoctoral Research Fellow (The Heart Institute; Cincinnati Children's Hospital Medical Center, Ohio, USA: 2006-2010)

Postdoctoral Research Associate (The Heart Institute; Cincinnati Children's Hospital Medical Center, Ohio, USA: 2010-2013)

Santanu Chakraborty, PhD, completed his doctorate degree in Molecular Physiology at the Miami University and a postdoctoral fellowship at the Cincinnati Children’s Hospital Medical Center, both in Ohio, USA. Dr. Chakraborty joined the Presidency University in April 2013 as an Assistant Professor in the Department of Biological Sciences (Zoology). He is interested in both embryonic heart development and adult heart diseases linked to cellular proliferation and extracellular matrix remodeling. His other research interests are to study the cross talk among different cardiac cell lineages including endothelial, myocardial and epicardial cells during development and disease. He is also interested in exploring the area of cardiac progenitor/stem cells and to study the functional significance of developmentally critical transcription factor gene re-activation following adult cardiac diseases using both in vivo and in vitro approaches.

American Association of Anatomists (AAA).

Member of the American Heart Association (AHA), Council on Basic Cardiovascular Science.

Life Member of Indian Society of Cell Biology (ISCB).

1. Maity J, Pal P, Ghosh M, Naskar B, Chakraborty S, Pal R, Mukhopadhyay P. Molecular dissection of the arsenic-induced leukocyte incursion into the inflamed thymus and spleen and its amelioration by co supplementation of L-ascorbic acid and α-Tocopherol. Biological Trace Element Research (2024) September 26 http://doi.org/10.1007/s12011-024-04378-z

2. Mondal A, Das S, Das M, Chakraborty S, Sengupta A. YAP1 - mediated dysregulation of ACE-ACE2 activity augments cardiac fibrosis upon induction of hyperglycemic stress. Biochimica et Biophysica Acta (BBA) - General Subjects (2024) September;1868(9):130666

3. Ghosh M, Khanam R, Sengupta A, Chakraborty S. Oxidative-stress induced Bmp2-Smad1/5/8 signaling dependent differentiation of early cardiomyocytes from embryonic and adult epicardial cells. Differentiation (2024) Mar-Apr:136:100756

4. Das S, Mondal A, Dey C, Chakraborty S, Bhowmik R, Karmakar S, Sengupta A. ER stress induced upregulation of transcription factor Tbx20 and downstream Bmp2 signaling to promote cardiomyocyte survival. Journal of Biological Chemistry (2023) Apr;299(4):103031

5. Mondal A, Das S, Samanta J, Chakraborty S, Sengupta A. YAP1 induces hyperglycemic stress-mediated cardiac hypertrophy and fibrosis in an AKT-FOXM1 dependent signaling pathway. Archives of Biochemistry and Biophysics (2022) Jun 15;722:109198.

6. Khanam R, Sengupta A, Mukhopadhyay D, Chakraborty S. Identification of Adamts4 as a novel adult cardiac injury biomarker with therapeutic implications in patients with cardiac injuries. Scientific Reports (2022) Jun 14;12(1):9898.

7. Samanta J, Mondal A, Das S, Chakraborty S, Sengupta A. Induction of cardiomyocyte calcification is dependent on Fox01/NFATc3/Runx2 signaling. In Vitro Cellular & Developmental Biology - Animal (2021) Dec;57(10):973-986

8. Dutta P, Sengupta A, Chakraborty S. Epigenetics: a new warrior against cardiovascular calcification, a forerunner in modern lifestyle diseases. Environmental Science and Pollution Research (2021) October 2; https://doi.org/10.1007/s11356-021-15718-0 (Review article in the special issue on “Mutagenic factors in the environment impacting human and animal health”)

9. Das S, Mondal A, Samanta S, Chakraborty S, Sengupta A. Unfolded protein response during cardiovascular disorders: a tilt towards pro-survival and cellular homeostasis. Molecular and Cellular Biochemistry (2021) Nov;476(11):4061-4080 (Review article)

10. Polley A, Khanam R, Sengupta A, Chakraborty S. Asporin reduces adult aortic valve interstitial cell mineralization induced by osteogenic media and wnt signaling manipulation in vitro. International Journal of Cell Biology (2020) Apr 10; 2020:2045969. eCollection 2020

11. Samanta J, Mondal A, Saha S, Chakraborty S, Sengupta A. Oleic acid protects from arsenic-induced cardiac hypertrophy via AMPK/FoxO/NFATc3 pathway. Cardiovascular Toxicology (2020) Jun;20(3):261-280

12. Sen P, Polley A, Sengupta A and Chakraborty S. Tbx20 promotes H9c2 cell survival against oxidative stress and hypoxia in vitro. Indian Journal of Experimental Biology  (2019) 57:643-655

13. Polley A, Sen P, Sengupta A and Chakraborty S. Beta Catenin stabilization promotes proliferation and increase in cardiomyocyte number in chick embryonic epicardial explant culture. In Vitro Cellular & Developmental Biology-Animal (2017) Dec;53:992-939

14. Chakraborty S, Sengupta A and Yutzey KE. Tbx20 promotes cardiomyocyte proliferation and persistence of fetal characteristics in adult mouse hearts. Journal of Molecular and Cellular Cardiology (2013) 62: 203-213

15. Sengupta A, Chakraborty S, Paik J, Yutzey KE and Evans-Anderson HJ. Fox01 is required in endothelial but not myocardial cell lineages during cardiovascular development. Developmental Dynamics (2012) Apr; 241(4): 803-813

16. Chakraborty S and Yutzey KE. Tbx20 regulation of cardiac cell proliferation and lineage specialization during embryonic and fetal development in vivo. Developmental Biology (2012) Mar 1; 363(1) 234-246

17. Chakraborty S, Wirrig EW, Hinton RB, Merrill WH, Spicer DB, Yutzey KE. Twist1 promotes heart valve cell proliferaion and extracellular matrix gene expression during development in vivo is expressed in human diseased aortic valves. Developmental Biology (2010) Nov 1; 347(1) 167-179

18. Chakraborty S, Combs MD, Yutzey KE. Transcriptional regulation of heart valve progenitor cells. Pediatric Cardiology (2010) Apr;13(3): 414-421 (Review article)

19. Alfieri CM, Cheek J, Chakraborty S, Yutzey KE. Wnt signaling in heart valve development and osteogenic gene induction. Developmental Biology (2010) Feb 15; 338(2):127-135

20. Chakraborty S, Cheek J, Sakthivel B, Aronow BJ, Yutzey KE. Shared gene expression profiles in developing heart valves and osteoblast progenitor cells. Physiological Genomics (2008) Sep 17;35(1):75-85 Epub 2008 Jul 8

21. Hlivko JT*, Chakraborty S*, Hlivko TJ, Sengupta S, James PF. The human Na,K-ATPase alpha4 isoform is a ouabain-sensitive alpha isoform that is expressed in sperm. Molecular Reproduction and Development (2006) Jan; 73(1): 101-115; *Equal contribution

22. Looney MR*, Sartori C*, Chakraborty S, James PF, Lingrel JB, Matthay MA. Decreased expression of both the alpha1- and alpha2-subunits of the Na-K-ATPase reduces maximal alveolar epithelial fluid clearance. Am J Physiol Lung Cell Mol Physiol (2005) Jul; 289(1): L104-10; * Equal contribution

Book Chapters:

1. Banerjee S, Sengupta A and Chakraborty S. Chapter 7: CRISPR-Cas9 Molecular scissors in medical biotechnology. In: Talukder P, Tandon R and Pal U. (eds) Exploring Medical Biotechnology - In Vivo, In Vitro, In Silico (2024; First edition). CRC Press; Taylor and Francis Group. DOI: 10.1201/9781003302131-8

2. Das S, Dey C, Chakraborty S and Sengupta A. Chapter 20: RNA Interference (RNAi) A boon to medical biotechnology. In: Talukder P, Tandon R and Pal U. (eds) Exploring Medical Biotechnology - In Vivo, In Vitro, In Silico (2024; First edition). CRC Press; Taylor and Francis Group. DOI: 10.1201/9781003302131-21

3. Das S, Mondal A, Samanta J, Chakraborty S, Sengupta A. Tale of Viruses in Male Infertility. In: Kesari, K.K., Roychoudhury, S. (eds) Oxidative Stress and Toxicity in Reproductive Biology and Medicine. Advances in Experimental Medicine and Biology (2022);1358:275-323. Springer, Cham. https://doi: 10.1007/978-3-030-89340-8_13