Anjoy Majhi

Assistant Professor

Post-doctoral fellow, Sep. 2012-Jan. 2013,  Wayne State University, Department of Biomedical Engineering, Detroit, USA with Prof. & Chair Juri Gelovani.

Post-doctoral fellow, Sep. 2010-Sep. 2012, The University of Texas M D Anderson Cancer Center, Department of Experimental Diagnostic Imaging, Houston, USA with Prof. & Chair Juri Gelovani.

Post-doctoral fellow, Oct. 2008-Sep. 2010, University of Houston, Department of Pharmacological and Pharmaceutical Sciences, Houston, USA with Prof. Joydip Das.

Research Associate Sept. 2007- Aug. 2008, Inha University, Incheon, South Korea with Prof. Sung Soo Kim.

Ph.D. Chemistry (Indian Institute of Chemical Technology/ Acharya Nagarjuna University, Sept., 2008), Hyderabad, India with Dr. Biswanath Das.

M.Sc. Chemistry, Organic Chemistry Specialization, (Jadavpur University, 2002)

B.Sc. Chemistry Hons. (Jadavpur University, 2000)

I did my PhD work at Indian Institute of Chemical Technology (IICT, Hyderabad) under Dr. Biswanath Das and awarded degree from Acharya Nagarjuna University, Guntur in Sep, 2008. After my thesis submission I went South Korea and joined Department of Chemistry, Inha University with Prof. Sung Soo Kim as Research associate during Sep, 2007 to Aug, 2008. After degree I moved to University of Houston, Department of Pharmacological and Pharmaceutical Sciences, Houston, USA for Post Doctoral research with Prof. Joydip Das during Oct, 2008 to Sep. 2010. Thereafter, I joined the research group of Prof. Juri Gelovani at The University of Texas M D Anderson Cancer Center, Department of Experimental Diagnostic Imaging, Houston, USA as Post Doctoral fellow during Sep, 2010 to Sep, 2012 and then Sep, 2012 onward I worked at Wayne State University, Department of Biomedical Engineering, Detroit, USA with Prof. Juri Gelovani. In Feb, 2013 I joined Presidency University as an Assistant Professor at the Department of Chemistry.

Approximately 15,000 new cases of childhood cancer are detected every year in India. This is almost double the incidence in the next highest country-the US. When diagnosed early enough and treated with the appropriate protocols, approximately 70% of childhood cancers are curable.  Tragically, while survival rates rise in the west, only 20% of children detected with cancer in India benefit from advanced medical care, translating into an unacceptably high number of children dying of their disease. Only few people in India are diagnosed with leukemia and blood-related cancers; a small fraction of the actual population. Treatment for cancer is complex. It varies with the type of cancer, and it is not the same for all patients. The treatment depends not only on the type of cancer, but also on certain features of the cancer cells, the extent of the disease, and whether the cancer has been treated before and cost of treatment. I would like to work on it, so my primary job is to synthesize small molecule and check their activity. 

List of Project 

Ongoing Project:

1. ICMR/DHR Resarch Grant (As Co-PI): "Molecularly Imprinted Fluorescent Test Strip for Direct, Rapid, and Visual Δ-9 Tetrahydrocannabinol (THC) Detection in Tiny Amount of Bio fluids". Rs. 28.3 lakhs, 2021-2024

2. ICMR/DHR Resarch Grant (As Co-PI): “Development of point of care molecularly imprinted fluorescent test strip for detection of urinary ethanol metabolites to assist in management of alcohol use disorder”.Rs. 29.77 laks, 2023-26

Completed Project As PI:

1. SERB-EEQ Research Grant (As PI): "Design and Development of Novel Small Molecule and Biophysical Studies for Drug Designing Process". (2019-2022, Sanction Order: EEQ/2019/000194, 26.11.2019)

2. DST-SERB Grant: "Development of Novel Thienopyrimidine for Pharmaceutical Composition to Eliminate Human Cancers and Imaging Lead". (Sanction Order no: SB/FT/CS-188/2012 dated 30.06.2014)

3. UGC Start up grant: "Development of novel protein kinase C (PKC) modulators for early diagnosis of human cancers and Imaging lead". (F. 30-19/2014 (BSR), F.D. Dy. No. 2161, Dated 19.06.2014)

Teaching:

UG-Courses Taught:

CHEM04C9: Nitrogen Containing compounds

CHEM05C11: Aminoacids, Peptides, Proteins and Nucleic acids

CHEM05DSE: Chromatography and Extraction

CHEM06C14: Dyes

DSE, SEC courses

Organic Chemistry Practical (Qualitative Analysis of solid & liquid compounds)

PG-Courses Taught:

CHEM0701: Stereochemistry 

CHEM0801: Heterocyclic Chemistry

CHEM 0891: Organic Practical

CHEM 0991A: Organic Special Practical-I 

Ph.D. Scholars:

1. Diya Sutradhar (PhD enrolled)

2. Sourav Pakrashy (PhD Registered)

3. Sourav Misra (PhD Registered)

4. Dr. Sandip Paul, (PhD Degree Awarded, June 8, 2022)

Student under SERB Projects:

1. Nasim Sepoy, 2. Sandip Paul, 3. Nakul Chandra Naskar, 4. Susmita Naskar 

Student Internship (SSR): 

1. Ankita Paul 

M.Sc., Students:

1. Arindam Ghosh (2013)

2. Moumita Dhara (2013)

3. Nasim Sepay (2014)

4. Anindita Ghosh (2014)

5. Poulami Chakraborty (2015)

6. Nandita Dey (2015)

7. Ankur Saha (2015) (ISM Dhanbad)

8. Shrabana Sarkar (2016)

9. Arindam Kundu (2016) 

10. Raju Ghanti (2017)

11. Anindita Das (2017)

12. Amit Kumar Ghosh (2017)

13. Rashmita Pan (2018)

14. Sawon Halder (2019)

15. Ritwika Dey (2019) 

16. Poulami Paul (2020)

17. Sayan Kumar Bag (2020)

18. Paromita Das (2021)

19. Arjun Ghosh (2021)

20. Asif Iqbal (2022)

21. Sayan Ghosh (2022)

22. Sunandana Ghosh (2023)

23. Md. Yasmidur Rahaman (2023)

24. Shreyasi Moulik (2023-24)

25. Prama Das (2023-24)

Life Member:

(i) Indian Science Congress Association

(ii) Chemical Research Society of India (CRSI)

 List of Publications: Journals: 48, h-index:20, i-index:35 (2024), Book Chapters: 4

https://scholar.google.com/citations?hl=en&user=fxOuaoAAAAAJ

Book Chapters:

1. Neuroprotective Effects of Phytochemicals in Brain Ageing

 Chapter Title: "Recent Advancement in the Use of Medicinal Plants in Brain Aging" -Sandip Paul, Anjoy Majhi*, Pinki Saha Sardar (2024), https://doi.org/10.1007/978-981-99-7269-2_14

2. Biomarkers in Cancer Detection and Monitoring of Therapeutics

Chapter Title: "Addressing the diagnosis and therapeutics of malignant tumor cells”- Anjoy Majhi*, Sandip Paul, Pinki Saha Sardar (2024), https://doi.org/10.1016/B978-0-323-95116-6.00010-4 

3. Cancer Stem Cells and Signaling Pathways

Chapter Title: "Chemical approaches to stem cell and signaling pathways for therapeutics" - Sandip Paul, Anjoy Majhi* (2024), https://doi.org/10.1016/B978-0-443-13212-4.00030-1           

4. Handbook of Animal Models and its Uses in Cancer Research.

Chapter Title ”Detection of Tumors Through Fluorescence Conjugated Dye in Animal Model”- Anjoy Majhi*, Sandip Paul, Pinki Saha Sardar. (2022) https://doi.org/10.1007/978-981-19-1282-5

Journals:

2024

1. Sourav Pakrashy, S. Chakraborty, S. Manna, J. N. Goswami, B. Bhattacharya, F. Emmerling, J. Mandal, Sourav Misra, S. M. Choudhury, M. K Okla, Adity Bose, P. K. Maurya, Anjoy Majhi* & M. Dolai. Inhibition of Human Colorectal Cancer by a Natural Product 7-Acetylhorminone and Interactions with BSA/HSA: Multispectral Analysis and In Silico and In Vitro Studies. ACS Applied Bio Materials (2024), 7, 5, 3414–3430. https://doi.org/10.1021/acsabm.4c00335 

2. Sourav Pakrashya, Anjoy Majhi* & Pawan K Maurya. Embelin as an alternative reference standard for Delta-9-Tetrahydrocannibinol. Indian Journal of Chemistry (IJC). Vol. 63, April 2024, 390-393, DOI: 10.56042/ijc.v63i4.7084

3. Sourav Misra, Sourav Pakrashy, Sandip Paul, Pawan Kumar Maurya, Pinki Saha Sardar, Adity Bose & Anjoy Majhi*. Interaction of a new triazole compound with Serum albumins and Proteolytic enzyme Bromelain by Steady state fluorescence and Molecular docking techniques. Indian Journal of Biochemistry and Biophysics. Vol. 61 (2024), 305-313., DOI: https://doi.org/10.56042/ijbb.v61i5.6123

2023

1. Sourav Misra, Sandip Paul, Sourav Pakrashy, Sayan Ghosh, Susmita Naskar, Pawan Kumar Maurya, Pinki Saha Sardar, Katta Venkateswarlu, Adity Bose & Anjoy Majhi*. De-Novo drug design of novel 1, 2, 3–triazole-naphthamide as an inhibitor of SARS-Cov-2 main protease: Synthesis, bioinformatics and biophysical. Indian Journal of Chemistry (IJC). Vol.62(10) (2023), 1001-1011, DOI: 10.56042/ijc.v62i10.1578

2. Anjoy Majhi*, K. Venkateswarlu, P. Sasikumar. Coumarin Based Fluorescent Probe for Detecting Heavy Metal Ions. Journal of Fluorescence (2023). https://doi.org/10.1007/s10895-023-03372-3.

2022

1. Shashi Kanth Boddu, Najeeb Ur Rehman, Tapan Kumar Mohanta, Anjoy Majhi, Satya Kumar Avula & Ahmed Al-Harrasi. A review on DBU-mediated organic transformations. Green Chemistry Letters and Reviews, 15 (3), 765–795, 2022. https://doi.org/10.1080/17518253.2022.2132836

2. Jangam Lakshmidevi, Bandameeda Ramesh Naidu, Satya Kumar Avula, Anjoy Majhi, Poh Wai Chia, Ahmed Al-Harrasi and Katta Venkateswarlu. A waste valorization strategy for the synthesis of phenols from (hetero)arylboronic acids using pomegranate peel ash extract. Green Chemistry Letters and Reviews, 15 (2), 427-436, 2022. https://doi.org/10.1080/17518253.2022.2082261

2021

1.    Sandip Paul, Pritam Roy, Sourav Das, Soumen Ghosh, Pinki Saha Sardar, and Anjoy Majhi*. "Addressing the Exigent Role of a Coumarin Fluorophore toward Finding the Suitable Microenvironment of Biomimicking and Biomolecular Systems: Steering to Project the Drug Designing and Drug Delivery Study." ACS Omega, 6 (18), 11878-11896, 2021.

2019

1.    Sandip Paul, Raju Ghanti, Pinki Saha Sardar, and Anjoy Majhi*. Synthesis of a Novel Coumarin Derivative and its Binding Interaction with Serum Albumins. Chemistry of Heterocyclic Compounds 2019, 55(7), 607–611.

2. Sandip Paul, Pritam Roy, Pinki Saha Sardar and Anjoy Majhi*. Design, Synthesis, and Biophysical Studies of Novel 1,2,3-Triazole- Based Quinoline and Coumarin Compounds. ACS Omega, 4, (2019) 7213.

2018

1. R. Bonomi, V. Popov, M. T. Laws, D. Gelovani, Anjoy Majhi, A. Shavrin, X. Lu, O. Muzik, N. Turkman, R. Liu, T. Mangner, and J. G. Gelovani. Molecular imaging of Sirtuin1 expression-activity in the rat brain using Positron Emission Tomography/Magnetic Resonance Imaging (PET/MRI) with [18F]-2-fluorobenzoylaminohexanoicanilide. J. Med. Chem (Just accepted, 27th Jul, 2018).

2017

1. S. Paul, N. Sepay, Shrabana Sarkar, Pritam Roy, Swagata Dasgupta, Pinki Saha Sardar and Anjoy Majhi*. Interaction of Serum Albumins with Fluorescent Ligand 4-Azido Coumarin: Spectroscopic Analysis and Molecular Docking Studies. New J. Chem. 41 (2017) 15392. 

2. Majhi A*, Holla H, Shinde D, Srinivasulu G, Sai Krishna A, Rao JV and Das B. Two novel polychiral furanopyrans from Orthosiphon diffusus (Benth.). Indian Journal of Chemistry Sect. B. 2017, 56B (8), 855-861.

2016

1. Pany S, Majhi A and Das J. Selective modulation of PKCα over PKCε by curcumin and its derivatives in CHO-K1 cells. Biochemistry. 2016, 55, 2135−2143; DOI: 10.1021/acs.biochem.6b00057.

2015

1. Bonomi R, Mukhopadhyay U, Shavrin A, H-H Yeh, Majhi A, Dewage W. S, Najjar A, Xin L, Cisneros GA,  Tong  PW,  Alauddin MM, Liu RS, Mangner JT, Turkman N, Gelovani GJ. Novel Histone Deacetylase Class IIa Selective Substrate Radiotracers for PET Imaging of Epigenetic Regulation in the Brain. PLoS ONE. 2015; 10(8): e0133512, doi:10.1371/journal.pone.0133512.

2012

1. Pany S, Majhi A and Das J. PKC Activation by Resveratrol Derivatives with unsaturated  Aliphatic Chain. PLoS ONE. 2012; 7(12): e52888; doi: 10.1371/journal.pone.0052888.

2011

1. Das J, Pany S, Panchal S, Majhi A and Rahman GM. Binding of isoxazole and pyrazole derivatives of curcumin with the activator binding domain of novel protein kinase C. Bioorganic and Medicinal Chemistry 19, 2011, 6196-6202.
2. Das J, Pany S and Majhi A. Chemical Modifications of Resveratrol for Improved Protein Kinase C alpha Activity. Bioorganic and Medicinal Chemistry 19, 2011, 5321-5333.
3. Holla H, Yallamalla S, Majhi A, Gannoju S, Balasubramanian S, Arepalli SK, Janapala VR and Das B. Novel cytotoxic constituents of Orthosiphon diffuses. Tetrahedron Letters 52, 2011, 49-52.

2010

1. Majhi A, Rahman GM, Panchal S and Das J. Binding of curcumin and its long chain derivatives to the activator binding domain of novel protein kinase C. Bioorganic and Medicinal Chemistry 18, 2010,1591-1598.

2009

1. Majhi A, Kim SS and Kadam ST. TMEDA Catalyzed Henry (Nitroaldol) Reaction under Metal and Solvent-free Conditions. Bull. Korean Chem. Soc. 30, 2009, 1767-1770.

2008

1. Majhi A, Kim SS and Kadam ST. Rhodium (III) iodide hydrate catalyzed three-component coupling reaction: Synthesis of α-aminonitriles from aldehydes, amines and trimethylsilyl cyanide. Tetrahedron 64, 2008, 5509-5514.
2. Majhi A, Kim SS and Kim HS. Copper perchlorate hexahydrate: A highly efficient catalyst for the cyanosilylation of aldehydes. Applied Organometallic Chemistry 22, 2008, 407-411.
3. Majhi A, Kim SS and Kim HS. Niobium (V) chloride-catalyzed synthesis of α-aminonitriles with simultaneous reaction of aldehydes, amines and trimethylsilyl cyanide. Applied Organometallic Chemistry 22, 2008, 466-470.
4. Majhi A, Kim SS and Kadam ST. Solvent-free synthesis of α-aminonitriles from aldehydes, amines and trimethylsilyl cyanide catalyzed by thallium (III) chloride tetrahydrate. Applied Organometallic Chemistry 22, 2008, 705-711.
5. Das B, Boddu SK, Majhi A and Reddy KR. An efficient chemo- and stereoselective synthesis of enaminones and enaminoesters using (bromodimethyl)sulfonium bromide under solvent-free conditions. Heteroatom Chemistry 19, 2008, 630-633.

2007

1. Das B, Katta V, Kanaparthy S and Majhi A. An efficient and convenient protocol for the synthesis of quinoxalines and dihydropyrazines via cyclization-oxidation processes using HClO4·SiO2 as a heterogeneous recyclable catalyst. Tetrahedron Letters 48, 2007, 5371-5374.
2. Das B, Majhi A, Chowdhury N, Reddy KR and Bommena R One-pot stereoselective synthesis of Cbz-protected β-amino ketones: Three-component coupling of aldehydes, ketones and benzyl carbamate. Chemistry Letter 36, 2007, 1106-1107.
3. Das B, Majhi A, Reddy KR and Katta V. I2-SiO2: An efficient heterogeneous catalyst for the Johnson-Claisen rearrangement of Baylis-Hillman adducts. Journal of Molecular Catalysis A: Chemical 263, 2007, 273-75.
4. Das B, Katta V, Majhi A, Siddaiah V and Reddy KR. A facile nuclear bromination of phenol and anilines using NBS in the presence of ammonium acetate as a catalyst. Journal of Molecular Catalysis A: Chemical 267, 2007, 30-33.
5. Das B, Majhi A, Reddy KR and Kanaparthy S. Rare-earth metal triflates catalyzed three-component coupling of aldehydes, ketones or ketoesters and benzyl carbamate: An efficient one-pot stereoselective synthesis of Cbz-protected β-amino carbonyl compounds. Journal of Molecular Catalysis A: Chemical 274, 2007, 83-86.

2006

1. Das B, Majhi A and Banerjee J. Treatment of Baylis-Hillman adducts with triethyl orthoacetate in the presence of heterogeneous catalysts: an interesting method for stereoselective synthesis of two different types of trisubstituted alkenes. Tetrahedron Letters 47, 2006, 7619-7623.
2. Das B, Banerjee J, Chowdhury N and Majhi A. Synthetic Applications of Baylis-Hillman adducts: A novel and efficient one-pot synthesis of (E)-α-methylcinnamic acids and synthesis of potent hypolipidemic agent LK-903. Chemical and Pharmaceutical Bulletin-Japan 54, 2006, 1725-1727.
3. Das B Katta V, Majhi A, Reddy MR, Reddy KN, Rao YK, Ravikumar K and Sridhar B Highly efficient, mild and chemoselective synthesis of enaminones using silica supported perchloric acid under solvent free conditions. Journal of Molecular Catalysis A: Chemical 246, 2006, 276-281.
4. Das B, Katta V, Krishnaiah M, Holla H and Majhi A. A rapid and efficient stereoselective synthesis of (Z) - and (E) - allyl bromides from Baylis-Hillman adducts using bromo(dimethyl)sulfonium Bromide. Helvetica Chimica Acta 89, 2006, 1417-1421.
5. Das B, Majhi A, Banerjee J and Chowdhury N. A convenient highly stereoselective synthesis of allyl amides from Baylis-Hillman adducts using Amberlyst-15 as a heterogeneous reusable catalyst. Journal of Molecular Catalysis A: Chemical 260, 2006, 32-34.
6. Das B, Banerjee J, Chowdhury N, Majhi A and Holla H. Remarkably Chemoselective Reduction of Unmodified Baylis-Hillman Adducts by InCl3-NaBH4: Application to the Stereoselective Synthesis of Trisubstituted Alkenones including Two Alarm Pheromones. Synlett 2006, 1879-1882.
7. Das B, Chowdhury N, Banerjee J and Majhi A. A facile one-pot stereoselective synthesis of trisubstituted (E)-2-methylalk-2-enoic acids from unactivated Baylis-Hillman adducts and a simple access to some important insect pheromones. Tetrahedron Letters 47, 2006, 6615-6618.
8. Das B, Majhi A, Banerjee J, Chowdhury N, Holla H, Kankipati H and Murthy USN An efficient synthesis of 2- benzoxepines from Baylis-Hillman adducts using heterogeneous catalyst. Chemical and Pharmaceutical Bulletin-Japan 54, 2006, 403-405.
9. Das B, Banerjee J, Chowdhury N, Majhi A and Gurram M Synthetic application of the Baylis-Hillman reaction: Simple and convenient synthesis of five important insects pheromones. Helvetica Chimica Acta 89, 2006, 876-883.
10. Das B, Chowdhury N, Banerjee J, Majhi A and Gurram M. A Facile Zn- mediated Stereoselective Synthesis of (E)- and (Z)-Trisubstituted Alkenes from Baylis–Hillman Adducts in Water and Its Application. Chemistry Letters 35, 2006, 358-359.
11. Das B, Banerjee J, Majhi A, Chowdhury N, Katta V and Holla H Isomerization of the Baylis-Hillman adducts using amberlyst-15 as a heterogeneous reusable catalyst: a simple and efficient stereoselective synthesis of [E]-cinnamyl alcohol derivatives. Indian Journal of Chemistry Sect. B 45B, 2006, 1729-1733.

2005

1. Das B, Majhi A, Banerjee J, Chowdhury N and Katta V. Fe3+-K-10 Montmorillonite Clay Catalyzed Friedel-Crafts Reaction of Unactivated Baylis-Hillman Adducts: An Efficient Stereoselective Synthesis of Trisubstituted Alkenes Containing a Benzyl Substituent. Chemistry Letters 34, 2005,1492-1493.
2. Das B, Majhi A, Banerjee J, Chowdhury N and Katta V. A highly efficient stereoselective synthesis of (Z)- and (E)- allyl iodides from Baylis-Hillman adducts. Tetrahedron Letters 46, 2005, 7913-7915.
3. Das B, Holla H, Katta V and Majhi A Organic reactions in water: An efficient one-pot synthesis of acyloxiranes from Baylis-Hillmann adducts using hypervalent iodine.Tetrahedron Letters 46, 2005, 8895-8897.
4. Das R, Geethangili M, Majhi A, Das B, Rao YK and Tzeng YM. A new highly oxygenated pseudoguaianolide from a collection of the flowers of parthenium hysterophorus. Chemical and Pharmaceutical Bulletin-Japan 53, 2005, 861-862.

2004

1. Das B, Banerjee J, Gurram M and Majhi A. Organic reaction in water: An efficient zinc mediated stereoselective synthesis of (E)- and (Z)-trisubstituted alkenes using unactivated alkyl halides. Organic Letters 6, 2004, 3349-3352.
2. Das B, Banerjee J, Majhi A and Gurram M. An efficient stereoselective synthesis of (E)- and (Z)-trisubstituted alkenes from unactivated Baylis-Hillman adducts using NaBH4/CuCl2.2H2O. Tetrahedron Letters 45, 2004, 9225-9227.